. Calcifications can also occur in a variety of other clinical settings and can be subjected to fine-needle aspiration (FNA). Since cutaneous calcific deposits may clinic A diagnosis of tumoral calcinosis was rendered and surgical excision was done. On gross examination, the lesion was found to be firm, irregular, and 3 × 2 cm in size. The cut section was gritty and showed whitish, chalky areas of calcification. Multiple sections were taken and stained with H and E and von Kossa stain Cutaneous calcinosis, also calcinosis cutis and cutaneous calcification, is calcification of the skin. It is benign in itself; however, the underlying cause may not be Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. Virchow initially described calcinosis cutis in 1855. Results of fine-needle aspiration cytology of a skin nodule may also be diagnostic. Previous Next
Cytology of calcinosis cutis: inflammatory pyogranulomatous inflammation surrounding mineral salts. Note the giant cell ( arrow ) In cytology, the morphology of calcium salts can be very different, ranging from basophilic pointed or coarse granulations to more typical formations with an amorphous, glassy, transparent and sometimes rhomboidal or. Calcinosis circumscripta, a more localized form of calcium deposition in the skin, can occur on pressure points such as the paws and elbows, at suture sites, and on the tongue, but has different underlying causes than calcinosis cutis Cytology was compatible with calcinosis cutis due to suspected iatrogenic hypercortisolism, with secondary pyoderma. The Phovia system, a device that emits fluorescent light energy (FLE), was used as an adjunct to systemic antimicrobial and topical (spray and shampoo) therapies
Definition: large painless calcified masses in periarticular soft tissues, including elbows, hips, only rarely knees Also called calcium hydroxyapatite deposition in soft tissue, metastatic calcification Usage is imprecise - also refers to hereditary condition associated with massive periarticular calcification and any massive collection of periarticular calcification (Radiographics 2006;26:871 Calcinosis cutis Calcinosis cutis is characterized by calcium salt deposits in dermal and epidermal tissues and is the second most common of the three skin disease donkeys. Because it is often linked to corticosteroid use, whether or not you see it frequently in your practice depends on your area's veterinary culture Calcinosis cutis is an uncommon condition characterized by the deposition of calcium salts in the subcutaneous tissues of the body. Calcifications can also occur in a variety of other clinical settings and can be subjected to fine-needle aspiration (FNA)
Histology of calcinosis cutis There are irregular deposits of intensely basophilic acellular material in the dermis and subcutaneous tissue (figure 1). The basophilia is so strong that the appearance is of a deep purple (figures 2, 3) Calcinosis cutis has two forms: Dystrophic - occurs when calcium levels in the blood are normal, but calcium salts are deposited in damaged tissues, or Metastatic - occurs when calcium levels in the blood are elevated and calcium is deposited in locally damaged tissues. Calcium deposits may occur in multiple areas
There are very few case reports on FNA cytology of idiopathic calcinosis cutis.5, 6 FNA samples yielding abundant calcium have differential diagnosis of calcified fibrous pseudotumor, calcified epidermal cyst, sarcoidosis, tuberculosis, lymphoepithelial lesion, pilomatricoma, osteitis fibrosa cystica, and extra skeletal osteosarcoma etc. Calcinosis cutis is an uncommon entity which develops due to the deposition of hydroxyapatite crystals of calcium phosphate in the skin. As the calcific deposits can clinically mimic a tumor, it is feasible to investigate them by fine-needle aspiration cytology (FNAC). In this study, we describe two cases of calcinosis cutis that were diagnosed by fine needle aspiration (FNA) Calcinosis circumscripta is deposits of calcium at bony prominences or in the footpads and mouth. It is usually a disease of large dog breeds and occurs before two years of age Calcinosis cutis is characterized by dystrophic calcium deposition in the dermis and subcutis due to phase transformation of calcium and phosphate ions from solution in to crystalline aggregate with deposition in matrices of dermal collagen and elastin. A four-year-old Scottish Terrier was received.
Calcinosis cutis is the deposition of calcium in the dermis, resulting from dystrophic or metastatic calcification. It is most commonly seen as a result of dystrophic calcification, which usually occurs more often in dogs than cats Key words: Calcinosis cutis, idiopathic, fine needle aspiration cytology INTRODUCTION Calcinosis cutis, initially described by Virchow in 1855 refers to a group of disorders characterized by deposition of calcium salts in the skin. Calcinosis cutis is classified into four major types according t
Calcinosis cutis in a background of chronic viral infection: Report of 2 cases: Diagnosed by fine needle aspiration cytology - IJPO- Print ISSN No: - 2394-6784 Online ISSN No:- 2394-6792 Article DOI No:- 10.18231/2394-6792.2019.0029, Indian Journal of Pathology and Oncology-Indian J Pathol Onco Calcinosis cutis is an uncommon condition, and calcific deposits in patients with end‐stage renal disease are now somewhat rare, due to improvement in management. Since calcific deposits may clinically resemble a tumor, it is feasible to investigate them by fine‐needle aspiration cytology (FNAC). A 52‐yr‐old male with a history of end‐stage renal failure presented with a 2‐cm mass.
Cytology confirmed accelerated improvement of the Phovia-illuminated lesions compared with unexposed lesions. To the authors' knowledge, this is the first report of FLE being used to manage bacterial skin infection associated with canine calcinosis cutis A hygroma is a false bursa that develops over bony prominences and pressure points, especially in large breeds of dogs. In young dogs the pathogenesis is believed to be due to trauma. In older dogs, hygromas tend to be result of impaired ambulation and excessive time spent in recumbency on hard surfaces. These are common in dogs with elbow.
Fine needle aspiration cytology (FNAC) followed by excisional biopsy was done. A final diagnosis of calcinosis cutis was made based on histopathological and clinical findings. This is a rare case of mixed variants/subtypes-subepidermal calcified nodules and milia like lesion We report a case of idiopathic calcinosis cutis diagnosed by fine needle aspiration cytology in a 50-yr-old female who presented with a subcu taneous swelling near the left iliac crest. Cytological finding of amorphous calcium salts with histiocytes and the appropriate clinical background led to the cytodiagnosis of idiopathic calcinosis cutis. Faulty production of hypophyseal hormones may rarely cause dermatoses. Hypopituitarism is characterized by alopecia, especially in the axillary regions and on the lateral thorax and abdomen. Hyperadrenocorticism also is manifest by skin changes such as hyperpigmentation, alopecia, seborrhea, calcinosis cutis, and secondary pyoderma
Calcinosis cutis (calcium deposits in the skin, typically occurs with Cushing's disease or long term steroid treatments) Ear margin dermatosis (crusts and hair loss on the edges of the ears) Hepatocutaneous syndrome (crusts and ulcers of around the mouth, eyes and footpads that progresses to liver disease, typically associated with diabetes On the topic of cells, we focus on the adrenal and pituitary glands. There are different types of hormones that travel to the tissues and organs via the bloodstream. Take the test below and see how much information you have on hormones, their generation, and their functions. All the best Although bacteria were not visualized, infection was still a likely consideration. Antibiotic therapy could have decreased the sensitivity of cytology in detecting bacterial organisms. In conclusion, the main differential diagnosis for these skin lesions was calcinosis cutis with secondary inflammation and possible infection Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs. A 14-year-old castrated male Poodle dog presented with an abdominal mass. On physical examination, hypertension, increased lens opacity, calcinosis cutis, generalized alopecia, and.
These include calcinosis cutis circumscripta, calcinosis cutis universalis, tumoral calcinosis, and transplant-associated calcinosis cutis. The term tumoral calcinosis was originally described by INCLAN in 1943. In all cases of calcinosis cutis, insoluble compounds of calcium are deposited within the skin due to local and or systemic. and cytology or biopsy was not performed in any patients. All seven patients underwent surgery. Patients were followed up at months 3 and 6 and years 1 and 2. Recurrence rate was Introduction: Calcium deposition in the skin has been termed as calcinosis cutis. Tumoral calcinosis is idiopathic form of calcinosis cutis Calcinosis cutis (CC) is a type of calcinosis wherein insoluble compounds or salts deposited on the skin. Clinical diagnosis of CC is usually achieved through time consuming histopathological or immunohistochemical procedures, but it can only be empirically identified by experienced practitioners
A 14-year-old castrated male Poodle dog presented with an abdominal mass. On physical examination, hypertension, increased lens opacity, calcinosis cutis, generalized alopecia, and systolic murmur were observed. Serum chemistry and urinalysis profiles revealed hyperglycemia, hypercholesterolemia, elevated liver enzymes, and glucosuria Idiopathic scrotal calcinosis: A brief case report - By Shivani Panhotra, Mohammad Jaseem Hassan, Shivali Sehgal, Sabina Khan, Sujata Jetley-IP Arch Cytol Histopathol Res Idiopathic Scrotal Calcinosis (ISC) is a rare benign lesion involving the scrotal skin which is characterized by the presence of single or multiple calcified nodules aspiration cytology was employed. After surgery the recurrence of the disease was reported in three cases. Keywords: calcinosis circumscripta, metastatic calcification, dystrophic calcification, dogs Generalized lesions Great Dane Pointer Post-injection lesions Poodle Lesions in the cheek, ear pinnae Boston Terrier Boxer Other dog breeds German. opacity, calcinosis cutis, generalized alopecia, and sys-tolic murmur (grade 3). Hematologic and serum bio- Fig. 1 Cytology from the fine-needle aspiration biopsy of a right adrenal mass diagnosed as pheochromocytoma in a dog. Neuroendocrine cells, with naked nuclei, anisokaryosis, prominent nucleoli, and coarse chromatin are seen (a).. A. Calcinosis cutis B. Osteoma cutis (also skin-colored or blue) II. Skin-colored A. Rheumatoid nodules B. Neurofibromas (von Recklinghausen's disease) C. Angiofibromas (tuberous sclerosis, MEN syndrome, type 1) D. Neuromas (MEN syndrome, type 2b) E. Adnexal tumors 1
Calcinosis cutis: Azure A: Mast cell: Mastocytosis: Bcl-2: Basal cell carcinoma Primary cutaneous marginal zone lymphoma Diffuse large B-cell lymphoma leg type: Bcl-6: Primary cutaneous follicular lymphoma: BerEp4: Desmoplastic trichoepithelioma Basal cell carcinoma: Brown-Brenn: Eumycotic mycetoma: CAM 5.2: Merkel cell carcinoma: CCR7. The owners had no clear idea why the prednisone was prescribed. He had severe polyuria and polydipsia. On physical examination, calcinosis cutis was seen, and he had difficulty walking. Pyoderma, inflammation, cocci and rods were present on cytology. CBC and a chemistry panel were performed demonstrating changes related to steroid administration
Agrawal P, Banik T, Dey P. Fine needle aspiration cytology of calcinosis cutis. ?. Diagn Cytopathol (in press). Banik T, Halder D, Gupta N, Dey P. Malignant mixed MÃ¼llerian tumor of the uterus: Diagnosis of a case by fine-needle aspiration cytology and review of literature. Diagn Cytopathol. 2011 Apr 6 This is called Calcinosis Cutis. MSH production stimulates the pigmentation of the skin with melanin. Cortisol inhibits the growth phase of the hair cycle (ANAGEN) so hair growth stops. When epilated over areas of high friction there will be bilaterally symmetric non-pruritic alopecia
senting for anal cytology. High-resolution anoscopy and biopsies were obtained as indicated. Sensitivity and specificity as well as rates of satisfactory specimens were determined for each method using the areas under the receiver operating characteristic curve (AUCROC) and McNemar's test, respectively. Perceived discomfort of each device was determined using a visual analog scale and compared. Calcinosis cutis in a background of chronic viral in fection: Report of 2 cases: D iagnosed by f ine needle aspiration cytology By IP Innovative Publication Pvt. Ltd. and kaneeka bhatnagar Incidental Idiopathic Calcinosis Cutis in a Rhytidectomy Patien Diagnosis: Cytology is usually the first step for a diagnosis of this disease. Collection of a sample from an intact pustule is ideal, but if that cannot be found, sampling the underside of an adherent crust will be adequate. diabetes, calcinosis cutis, secondary opportunistic bacterial skin and/or urinary tract infections, and upper.
Calcinosis cutis is a term used to describe a group of disorders in which circumscribed calcium deposits form in the dermis of the skin in various parts of the body. It is classified into four major types: metastatic, dystrophic, idiopathic, and subepidermal calcified nodule [ 2 ] Section 3. Lack of metabolic activity as demonstrated on PET/CT narrowed the differential diagnosis to fibrous dysplasia or a benign primary osteogenic tumor such as osteoblastoma. 1 Given the patient's history of systemic scleroderma, diffuse calcinosis of the neck was also considered. Fine-needle aspiration cytology revealed necrotic tissue with calcifications Canine atopic dermatitis (CAD) is a common pruritic skin disease affecting dogs worldwide. It likely affects 10-15% of dogs. In regions where fleas are not a problem, CAD is the most common canine allergic skin disease. Clinical signs are first noted between 6 months and 3 years of age. Several breeds are over represented including the Boston. Pemphigus Foliaceus. Transmission or Cause: Pemphigus foliaceus is an autoimmune disease whereby antibodies produced by an animal's own immune system attack the bridges that hold skin cells together.It is the most common autoimmune disease diagnosed in dogs and cats. Affected Animals: Dogs and cats of any age or gender can be affected. In dogs, Akitas, Chow Chows, Doberman Pinschers. Calcinosis cutis: neck. Calcinosis cutis: superficial. Cerebrospinal fluid: xanthochromic. CT: Adrenal: mass transverse - soft tissue window. Cytology: agglutination of erythrocyte - auto-immune hemolytic anemia. Cytology: band neutrophil - auto-immune hemolytic anemia.